Guides
Explainers on the file formats, identifiers and descriptors behind the tools — written for people who need to get the chemistry right, not a textbook summary.
SMILES vs InChI vs InChIKey: What Is the Difference?
Three text formats describe the same molecule in three different ways. Choosing the wrong one is a common source of duplicate records and broken lookups.
Read guide →Lipinski's Rule of Five: A Practical Guide
The rule of five is the most quoted heuristic in drug discovery and the most misused. Here is what it measures, what it does not, and how to run it on a molecule in seconds.
Read guide →FASTA vs FASTQ: What Is the Difference?
Both formats hold nucleotide sequences. One carries per-base quality scores and one does not — and that single difference decides which pipelines will accept your file.
Read guide →